We conduct drug validated behavioral assays for the following:
- Anxiety
- Depression
- Psychosis
- Pain
- Sleep
- Drug Addiction
- Obesity
- Learning and Memory
- Phenotypic Assessment/Behavioral Toxicology
- Custom Assays / Other services
- Pogorelov platform test (analog of light:dark test - validated with chlordiazepoxide (CDZ), buspirone, amphetamine (anxiogenic effect), yohimbine
- Fear-potentiated Startle (validated with CDZ)
- Vogel conflict test (validated with CDZ)
- marble burying (validated with CDZ, fluoxetine)
- stress-induced hyperthermia (validated with diazepam)
- tail suspension (validated with fluoxetine, imipramine, nomifensine, paroxetine, citalopram, bupropion).
- forced swim (validated with fluoxetine, imipramine, reboxetine, paroxetine, nomifensine)
- maternal separation model (consistent increase in TS immobility demonstrated in separated animals when tested at adult age, compared to non-separated controls; also changes in neurotransmitters and metabolites in relevant brain regions)
- pre-pulse inhibition of acoustic startle response (validated with clozapine, risperidone, PCP, amphetamine)
- amphetamine/PCP-induced hyperlocomotion
- conditioned avoidance response (validated with raclopride)
- hot and cold plate tests (validated with morphine)
- formalin paw test (validated with morphine, gabapentin, ketorolac)
- shock-reactivity test (validated with morphine)
- Chung model (mice and rats, validated with gabapentin)
- Sleep (EEG-telemetry)
- circadian activity
- continuous darkness challenge
- sleep deprivation challenge
Obesity
Learning and Memory
- trace and delay fear conditioning (validated with nicotine, scopolamine)
- novel object recognition (validated with scopolamine)
- 5-choice serial reaction time, 5-CSRT (validated with nicotine, ciproxifan)
- conditioned avoidance response
- Morris water maze - standard or Atlantis platform (validated with scopolamine, nicotine)
- Irwin screen
- home cage observation
- open field
- inverted screen
- rotorod for motor strength and coordination assessment
- acoustic startle reactivity (hearing test, followed by ABR if differences noted)
- visible platform task in Morris water maze (vision test, followed by ERG if differences detected)
- Blood Pressure, Heart Rate and EKG
Custom assays upon request
Other services include:- Behavioral Safety Assessments
- Biochemistry and Biomarkers
- Microdialysis
- PK Studies
- Histopathology
- Molecular Biology
- Development of Biomarker Strategies
Routes of dosing include: IP, PO, SC, ICV, IM, intranasal, and infusions via cannula to discrete brain regions